Phthalate Safety Concerns Merit Substitute Products
By Ted Schettler, M.D., MPH.
February 28, 2006
As evidence of the hazards of di-2-ethylhexyl phthalate (DEHP)
Continues to mount, the inevitable question arises, "When do we know enough to
act to protect people from unnecessary and potentially harmful exposures?"
Concerns about the safety of DEHP, a PVC plasticizer, have intensified
since it became apparent that developing organisms are far more
susceptible to DEHP exposures than adults. Hundreds of animal studies
confirm the particular vulnerability of the developing male
Reproductive system and have begun to define mechanisms of toxicity, including
impaired testosterone synthesis. Birth defects, pathologic testicular
changes, decreased sperm production, and altered hormone levels are
caused by developmental exposures to DEHP. Lowest adverse effect levels
in developing organisms are orders of magnitude lower than doses
necessary to cause reproductive system impacts in adults. (excerpt)
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